Comparison of Metformin With Vitamin D Supplementation and Metformin Alone in Terms of Reduction in Level of HbA1c in Patients Diagnosed With Diabetes Mellitus Type II

This study found that adequate vitamin D status is necessary for metformin to effectively reduce prolactin levels in men with iatrogenic hyperprolactinemia, while improvements in glycemic control were observed across all vitamin D groups.

This study found that high-dose vitamin A and E supplementation with zinc may improve glycemic control and beta-cell function in patients with type 2 diabetes, compared to no supplements.

In this study, vitamin D supplementation showed no significant effect on androgen levels or clinical hyperandrogenism in PCOS women, but when combined with metformin, it improved testosterone levels.

This randomized clinical trial found that vitamin D supplementation did not significantly alter anthropometric or metabolic parameters in obese, insulin-resistant, and vitamin D-deficient women with polycystic ovary syndrome, whereas metformin effectively reduced body weight, BMI, waist circumference, total body fat, and serum glucose levels.

In this study, the authors concluded that metformin and vitamin D are important for managing PCOS by improving insulin resistance and hormonal imbalances, especially in women with a BMI of 25 kg/m² or higher.