Paclitaxel and Platinum Combination Regimen and Alopecia

    January 2012 in “ Türk jinekoloji ve obstetrik derneði dergisi/Türk Jinekoloji ve Obstetrik Derneği dergisi ”
    Nejat Özgül, Özlem Erten, Soner Düzgüner, Taner Turan, İskender Kög, Nurettin Boran, İlknur Balta, Mehmet Köse
    Studysummary This study observed that over 90% of patients undergoing paclitaxel and platinum chemotherapy for certain gynecological cancers experienced significant, yet reversible, alopecia by the end of treatment.
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    The study retrospectively evaluated alopecia in 470 patients treated with a paclitaxel and platinum combination for various gynecological cancers from 1993 to 2006. Patients received 6 cycles of chemotherapy with either paclitaxel and carboplatin or paclitaxel and cisplatin. Grade 3 alopecia was observed in 91.7% of patients, with no cases of grade 4 alopecia. The severity and frequency of alopecia were similar between the two chemotherapy combinations. Alopecia became more pronounced with additional chemotherapy cycles but was reversible after treatment concluded.
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