Taxane-Induced Alopecia: A Historical Review of Patients With Ovarian or Breast Cancer Treated With Paclitaxel, Docetaxel, or Paclitaxel Poliglumex

    June 2005 in “ Journal of Clinical Oncology ”
    EA Calhoun, E. E. Welshman, Samuel M. Brown
    TLDR PPX causes much less hair loss than traditional taxanes.
    The study reviewed the incidence of alopecia in patients with ovarian or breast cancer treated with paclitaxel, docetaxel, or paclitaxel poliglumex (PPX). It was found that traditional taxanes like paclitaxel and docetaxel caused high rates of alopecia, with 87% of paclitaxel-treated and 74.2% of docetaxel-treated patients experiencing hair loss. In contrast, PPX, a macromolecular drug conjugate, resulted in significantly less alopecia. In a phase 2 trial, only 7% of patients experienced mild hair thinning, and no grade 3 alopecia was observed among 275 patients treated with PPX. The study concluded that PPX offered effective taxane therapy with minimal alopecia, thus potentially improving patients' quality of life.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Alopecia Areata Question

      in Treatment  2 upvotes 4 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community 29M alopecia or normal hair fall but something worked. Just wanted to share.

      in Update  3 upvotes 3 months ago
      A 29-year-old male experienced hair loss and found improvement using a combination of onion hair oil, castor oil, ketoconazole shampoo, and aloe vera gel with vitamin E, while discontinuing minoxidil and finasteride due to side effects. He emphasizes the importance of scalp massage and oiling for hair growth and reduced hair fall.

      community mbp alopecia areata or vitamin deficiency

      in Chat 1 year ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Androgenic alopecia exclusively on the vertex of the scalp

      in Chat  6 upvotes 1 year ago
      A user experienced androgenic alopecia starting at the vertex without frontal hairline recession and is seeking information on this pattern. Another user noted that vertex or diffuse hair loss is common among men.

    Similar Research

    5 / 1000+ results