Keloids After Herpes Zoster: Report of Wolf’s Isotopic Phenomenon and Literature Review

August 2023 in “ Clinical Cosmetic and Investigational Dermatology ”

Jian Wang, Huiliang Shen

keloids herpes zoster Wolf's isotopic response viral pathogenesis vascular pathogenesis immunological pathogenesis neurological pathogenesis shingles

TLDR Keloids can form at the site of a healed herpes zoster infection, but the reason is unclear.

Wolf's isotopic response (WIR) involves the emergence of a new skin disorder at the site of a previously healed skin condition, commonly following herpes zoster. The pathogenesis of WIR after herpes zoster is not well understood, despite various proposed theories such as viral, vascular, immunological, and neurological explanations. This report presents a case of a 76-year-old patient who developed keloids at the site of a previous herpes zoster infection. The study reviews clinical characteristics and explores potential theoretical reasons for the development of keloids following herpes zoster.

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