The Use of Liposomes in the Topical Application of Steroids

    May 1984 in “ Journal of Pharmacy and Pharmacology ”
    A.J.M. Vermorken, M.W.A.C. Hukkelhoven, A. M. G. Vermeesch-Markslag, C. M. A. A. Goos, Peter Wirtz, J Ziegenmeyer
    Studysummary This study found that while systemic absorption of DHT from liposomes was negligible, the topical biological effect was weaker compared to DHT dissolved in acetone on the female hamster flank organ model.
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    The study evaluated the topical application of 5 alpha-dihydrotestosterone (DHT) using the female hamster flank organ model. DHT encapsulated in liposomes showed negligible systemic absorption compared to significant absorption from an acetone solution. However, the biological effect of DHT was reduced when delivered via liposomes. Under the experimental conditions, the liposome system did not offer any advantages over the acetone solution for DHT application.
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