Ixekizumab Improved Refractory Erythrodermic Psoriasis With Comorbid Diffuse Alopecia: A Case Report With 52-Week Follow-Up

August 2024 in “ Clinical Cosmetic and Investigational Dermatology ”

Biao Song, Xiaohan Liu, Hongzhong Jin

ixekizumab erythrodermic psoriasis diffuse alopecia alopecia psoriatic skin lesions

Studysummary In this case report, a patient with severe erythrodermic psoriasis and diffuse alopecia who was unresponsive to conventional treatments showed complete resolution of skin lesions and alopecia after being treated with ixekizumab.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This case report discusses a patient with severe erythrodermic psoriasis (EP) and diffuse alopecia, conditions that significantly affect quality of life. The patient did not respond to conventional treatments but showed complete resolution of both psoriatic skin lesions and alopecia after being treated with ixekizumab for 52 weeks. This suggests that ixekizumab may be an effective treatment option for patients with refractory EP and associated alopecia.

View this study on dovepress.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Autoimmunity and Autoimmune Co-Morbidities in Psoriasis

49 citations , January 2018 in “Immunology”

This review discusses the relationship between psoriasis and autoimmunity, focusing on autoimmune co-morbidities, but reports no new research findings.

research Psoriatic Alopecia

41 citations , July 2015 in “Clinical and Experimental Dermatology”

This review explores the connection between psoriasis and hair loss, noting that both the disease and its treatments can contribute to alopecia, and reports no new clinical results.

Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

research Psoriatic Alopecia/Alopecia Areata–Like Reactions Secondary to Anti–Tumor Necrosis Factor-α Therapy: A Novel Cause of Noncicatricial Alopecia

72 citations , February 2011 in “The American Journal of Dermatopathology”

This study found that anti-TNF therapy-induced alopecia exhibits distinct clinical and histopathological features and can mimic psoriatic alopecia and alopecia areata, with some patients improving with topical treatment.