Isolation and Characterization of Sweat Gland Myoepithelial Cells from Human Skin

    January 2014 in “ Cell Structure and Function ”
    Ryuichiro Kurata, Sugiko Futaki, Itsuko Nakano, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama, Kiyotoshi Sekiguchi
    TLDR Human sweat glands contain stem cells capable of self-renewal and forming different cell types.
    The study investigated the presence of stem cells in human sweat glands, focusing on myoepithelial cells. Researchers identified stem cell markers CD29 and Notch among α-smooth muscle actin-positive myoepithelial cells. They isolated a CD29(hi)CD49f(hi) subpopulation from human skin, which demonstrated the ability to differentiate into sweat gland luminal cells and exhibited long-term proliferative potential. This indicated that the CD29(hi)CD49f(hi) myoepithelial subpopulation contained stem cells with self-renewal ability and multipotency, providing evidence of stem cells in human sweat glands.
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