Intravital Imaging of Host–Parasite Interactions in Skin and Adipose Tissues

    March 2019 in “ Cellular Microbiology ”
    Mariana De Niz, Gavin R. Meehan, Nicolas M. B. Brancucci, Matthias Marti, Brice Rotureau, Luísa M. Figueiredo, Friedrich Frischknecht
    Studysummary This review discusses the advancements enabled by intravital microscopy in understanding host-parasite interactions in living animals and reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.
    The document reviewed the use of intravital microscopy (IVM) to study host-parasite interactions in skin and adipose tissues, providing insights into the behavior and transmission of parasites like Plasmodium, Trypanosoma, and Leishmania. IVM allowed visualization of these interactions at cellular levels, revealing the skin as a key entry point and reservoir for parasites, while adipose tissue played a role in parasite biology. The study of Plasmodium spp. highlighted sporozoite migration and behavior, with implications for malaria research. IVM also showed the skin as a reservoir for Trypanosoma brucei and explored immune responses in Leishmania infections. The document emphasized the potential of IVM in advancing the understanding of parasite dynamics and host immune responses, suggesting future research directions using humanized models and technological advancements.
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