Intradermal platelet-rich plasma for the treatment of melasma: A clinical and dermoscopic evaluation in dark skin

The study concluded that intradermal platelet-rich plasma (PRP) significantly improved melasma in dark skin after 12 weeks of treatment, with no relapse observed even after 3 months. PRP was suggested as a potential first-line treatment, especially when combined with strict sun protection, due to its longer-lasting results. The study highlighted the lack of research on PRP's effects on dark skin, which is typically more resistant to treatment. It also emphasized that clinical improvement alone should not determine the cessation of treatment, as relapse risks remain. Dermoscopic evaluation was recommended to assess changes in vasculature and pigmentation, providing better indicators of treatment success.