Insulin Resistance and Chronic Inflammatory Dermatoses

The document discusses the role of insulin resistance (IR) in the development of skin diseases, particularly psoriasis, acne, and androgenetic alopecia. Insulin resistance is a disrupted response of the body's peripheral tissues to insulin, and patients with chronic skin conditions have a higher risk of developing it. The connection between IR and metabolic syndrome is due to various molecular factors, with adipokines being a key player. The authors conclude that IR is a significant independent factor in the development of many inflammatory skin diseases, both on its own and through associated metabolic disorders. Excessive body weight and obesity are strongly linked with IR and a more severe course of skin diseases, suggesting the importance of determining HOMA-IR in patients. The severity of chronic inflammatory skin diseases (psoriasis, adult acne, and androgenetic alopecia) is seen as an independent predictor of IR.