In Vitro Skin Permeation of Monoolein Nanoparticles Containing Hydroxypropyl β-Cyclodextrin/Minoxidil Complex

    April 2010 in “ International Journal of Pharmaceutics ”
    Teak Kwan Kwon, Jin-Chul Kim
    Image of study
    TLDR Nanoparticles improve minoxidil skin permeation, but more research needed for effective hair growth.
    The study aimed to improve the skin permeation of minoxidil, a drug used to treat hair loss, by developing a topical preparation that reduces the barrier function of skin and enhances the permeation of the active ingredient through skin. The researchers prepared monoolein cubic phase nanoparticles containing hydroxypropyl β-cyclodextrin/minoxidil complex and found that the nanoparticles had higher in vitro skin permeation of minoxidil loaded than that of minoxidil dissolved in propylene glycol/water/ethanol. However, the amount of minoxidil remained within the skin was higher with the minoxidil solution than with the nanoparticles. The study concluded that further research is needed to increase the skin retention of the nanoparticles for effective hair growth promotion.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 1000+ results

      community manager told me i have to stop using minoxidil

      in Minoxidil  576 upvotes 3 days ago
      A manager told an employee to stop using minoxidil, fearing it could unintentionally cause hair growth in others. The conversation is filled with humorous and sarcastic responses, questioning the manager's logic and suggesting the employee continue using the treatment secretly.

      community Minoxidil its giving me huge water retention

      in Minoxidil  128 upvotes 1 week ago
      Minoxidil caused water retention and gastrointestinal issues for the user, which improved after stopping the medication. The user is now using finasteride and topical minoxidil, experiencing excessive urination and concerns about systemic absorption.

      community Should I add oral minoxidil right now?

      in Minoxidil  85 upvotes 2 weeks ago
      The user is considering adding oral minoxidil to their current hair loss treatment, which includes dutasteride and occasional finasteride, due to concerns about hair thinning and potential shedding. They are unsure if starting both treatments simultaneously could worsen shedding or if oral minoxidil might be beneficial.

      community Stoped minoxidil 5 weeks ago and still bloated

      in Minoxidil  167 upvotes 3 weeks ago
      The user stopped using minoxidil 5 weeks ago due to facial swelling, which initially subsided but then returned. Despite a healthy lifestyle and normal test results, the user is concerned about the persistent bloating.

    Related Research

    2 / 2 results