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    January 2018 in “ Journal of the American Academy of Dermatology ”
    Lucy Liu, Brett King
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    TLDR Combining pulsed prednisone with tofacitinib can lead to lasting hair regrowth in severe alopecia areata patients.
    The authors responded to comments on their study about the use of the Severity of Alopecia Tool (SALT) score in alopecia areata patients, explaining that the percent change in SALT score is a standard measure and that absolute change would yield similar results given the initial scores. They defended their decision to highlight nonresponders separately rather than grouping them with responders. They acknowledged that hair regrowth from pulsed prednisone is typically lost after withdrawal, but noted that combining pulsed prednisone with tofacitinib led to sustained regrowth in patients not responding to tofacitinib alone. They emphasized the potential of Janus kinase inhibitors for treating severe alopecia areata and called for large trials to further investigate their efficacy.
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