Immunological and Histological Studies of Different Concentrations of Rosmarinus Officinalis and Thymus Vulgaris Extracts on Thymus Gland of Chick Embryos

July 2023 in “ Toxics ”

Reem Yahya Alzahri, Fawzyah Abdullah Al-Ghamdi, Seetah Saleem Al-Harbi

Rosmarinus officinalis Thymus vulgaris thymus gland IL-10 IgM IgG rosemary thyme

TLDR High concentrations of rosemary and thyme extracts can damage thymus tissue and affect immune markers in chick embryos.

This study investigated the effects of rosemary and thyme extracts on the thymus gland and immune markers (IL-10, IgM, and IgG) in chick embryos, using 160 fertilized eggs divided into 8 groups. The study found that high concentrations of these extracts caused simple damage to thymic tissue and reduced cell density. Specifically, high thyme concentrations significantly decreased IgM levels, while high rosemary concentrations and mixed treatments decreased IgG levels. IL-10 levels decreased on the 14th day but increased by the 20th day. Despite some benefits, the extracts also induced inflammation in the embryos.

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