Ichthyosis Hystrix: A Rare Case in a Three-Day-Old Male Infant

Ichthyosis hystrix, a rare skin disorder characterized by massive hyperkeratosis resembling spiny scales, was described in a 3-day-old male with extensive verrucous hyperpigmented lesions following Blaschko's lines, resulting in alopecia in affected areas. The patient exhibited no systemic abnormalities, and routine laboratory tests were normal. The condition, first noted in the 18th century, involves mutations in the keratin-1 gene and presents with varied clinical expressions. Treatment is primarily symptomatic, with topical retinoids and etretinate showing some benefit.