Evaluation of Hyperandrogenemia in Women with Prolactinoma

    March 2020 in “ Endocrinology research and practice. ”
    Mehmet Çağrı Ünal, Züleyha Karaca, Kürşad Ünlühızarcı, Fahrettin Kelestimur
    TLDR Treating prolactinoma doesn't significantly affect hirsutism or cause high androgen levels.
    The study evaluated hyperandrogenism in 20 women with prolactinoma compared to 15 healthy controls, focusing on changes before and after cabergoline treatment. Results showed that prolactinoma patients had higher prolactin levels, which normalized post-treatment, and lower estradiol levels, which did not significantly increase after treatment. Sex hormone-binding globulin levels increased significantly after treatment. Basal levels of androstenedione, DHEAS, 17-OH progesterone, 11-S, and cortisol were similar between groups, but DHEAS and androstenedione levels decreased significantly after treatment in prolactinoma patients. Acne, hirsutism, and androgenic alopecia were similar in both groups. Polycystic ovary was more frequent in prolactinoma patients, with some improvement post-treatment. The study concluded that hyperprolactinemia might not cause significant hyperandrogenemia or hirsutism, and treating hyperprolactinemia did not significantly improve hirsutism scores.
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