Correlation Analysis of Hypothalamic-Pituitary-Adrenal Axis Hormone Levels in Hair Before Stroke Onset and Mood Disorders After Stroke

    June 2024 in “ Rehabilitation Medicine ”
    Tiantian WANG, Yuanyuan Jia, Deyi QI, Huihua Deng, Dianhuai Meng
    The study investigated the levels of hypothalamic-pituitary-adrenal axis hormones, specifically cortisol (F) and cortisone (E), in hair before stroke onset and their correlation with post-stroke mood disorders in 62 stroke patients and 40 healthy controls. Results showed that F and E levels were significantly higher in patients with post-stroke depression and anxiety compared to non-depressed, non-anxious, and healthy individuals. These hormone levels were positively correlated with depression and anxiety scores, suggesting they could serve as potential predictors for post-stroke mood disorders. DHEA levels showed no significant difference between groups. The study provides cut-off values for F and E in hair for diagnosing post-stroke depression and anxiety, with varying sensitivity and specificity.
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