A New Look at an Old Option in the Treatment of Early-Stage Prostate Cancer: Hormone Therapy as an Alternative to Watchful Waiting

September 1998 in “ Medical hypotheses ”

Feng Yang, Paul Y. Song, Jeffrey D. Wayne, Florin Vaida, Srinivasan Vijayakumar

hormone therapy flutamide finasteride androgen blockade Propecia

TLDR Hormone therapy might be a proactive alternative to watchful waiting for early-stage prostate cancer, potentially improving survival without aggressive treatment downsides.

The document discussed the potential of hormone therapy as an alternative to watchful waiting in the treatment of early-stage, low-grade prostate cancer. It highlighted the high costs and risks associated with surgery and radiotherapy, which do not show a clear survival benefit over observation. The authors proposed using two oral hormonal agents, flutamide and finasteride, to achieve complete androgen blockade. This approach aimed to address patient concerns about leaving cancer untreated and suggested that hormone therapy might improve symptom-free survival and possibly overall survival.

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Research cited in this study

3 / 3 results

research Incidence of Liver Toxicity Associated with the Use of Flutamide in Prostate Cancer Patients

116 citations, May 1992 in “The American Journal of Medicine”

Flutamide rarely causes liver toxicity in prostate cancer patients.

research Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers

147 citations, April 1990 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride safely lowers DHT levels without affecting testosterone.

research Benign Prostatic Hyperplasia: A Disorder of Androgen Metabolism in Males

23 citations, May 1984 in “Journal of the American Geriatrics Society”

Benign Prostatic Hyperplasia may be caused by changes in how the body processes male hormones.

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Hair regrowth treatments for cis-males include Minoxidil, Finasteride, and RU58841. Estrogen and testosterone blockers can help restore hair loss but may not suit everyone.

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community 5 years of trying different hairloss treatment.

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The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

community 5 month results on natural protocol, i made a post after 3 mont of treatment wich you can find in my profile. I used different massages(detumescence therapy, wooden brush, tom hagerty exercises)vitamins(d3,fish oil, biotin,msm, magnesium) drank green tea and ate pumpkin seeds( reduces dht)

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research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations, November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.