Hormonal Status in Postmenopausal Androgenetic Alopecia

December 1992 in “ International Journal of Dermatology ”

S. Georgala, K. Gourgiotou, S. Kassouli, John Stratigos

testosterone estradiol sex hormone binding globulin SHBG androgenetic alopecia androgen receptors hair follicle keratinocytes DHEA-S free testosterone 3,17-androstanediol glucuronide testosterone estradiol SHBG androgenic alopecia androgen receptors hair follicle cells DHEA-S free testosterone 3,17-androstanediol glucuronide

TLDR No significant hormone differences found in postmenopausal women with androgenetic alopecia.

This study aimed to determine the serum levels of testosterone, estradiol, and sex hormone binding globulin (SHBG) in postmenopausal women with androgenetic alopecia and healthy controls. The results showed no statistically significant differences in hormone levels between the two groups, suggesting that a genetically determined functional alteration of androgen receptors and/or a metabolic disturbance may exist in the hair follicle keratinocytes in androgenetic alopecia. The study contradicts previous findings that reported high serum concentrations of DHEA-S, free testosterone/SHBG, and 3,17-androstanediol glucuronide/SHBG ratios, as well as low SHBG levels in women with androgenetic alopecia.

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Research cited in this study

2 / 2 results

research Androgenic Alopecia in Females: Diagnosis and Treatment

14 citations, July 1987 in “Dermatologic Clinics”

The document concludes that treating female hair loss should target reducing excess androgen and blocking its effects on hair follicles, with the best treatments being hormonal therapy, adrenal suppression, and topical minoxidil.

Female Androgenic Alopecia: The 3 Alpha, 17 Beta-Androstanediol Glucuronide/Sex Hormone Binding Globulin Ratio as a Possible Marker for Female Pattern Baldness

research Female Androgenic Alopecia: The 3 Alpha, 17 Beta-Androstanediol Glucuronide/Sex Hormone Binding Globulin Ratio as a Possible Marker for Female Pattern Baldness

13 citations, September 1986 in “Archives of Dermatology”

Women with more 3α,17β-androstanediol glucuronide compared to sex hormone binding globulin are more likely to have female pattern baldness.

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