Histological Features of Melasma Lesions and the Expression of Keratin 10

    January 2010 in “ Chinese Journal of Aesthetic Medicine ”
    Biao Cheng
    TLDR Melasma skin has more melanin and signs of aging, with strong CK10 expression linked to cell differentiation and aging.
    The study investigated histological changes in melasma-affected skin and keratin 10 (CK10) expression. It found that melasma skin had a thinner epidermis with increased melanin around basal layer cells, extending to the upper basal layer, upper hair follicle, and dermis. Dermal collagen was disordered and fractured, with fewer skin appendages compared to normal skin. CK10 was primarily found in the upper stratum of the basal epidermis and the outer layer of sebaceous glands. The study concluded that melasma skin showed increased melanin content and features of skin aging, with strong CK10 expression potentially linked to excessive epidermal cell differentiation and aging.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 6 results

      community Does finasteride/dutasteride reverse aging?

      in Chat  45 upvotes 1 year ago
      Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

      community 34 Year old male - 20 month Finasteride 1.25 mg / day

      in Progress Pictures  661 upvotes 6 months ago
      A 34-year-old male experienced significant hair regrowth and increased density after 20 months of using 1.25 mg of finasteride daily, with no noticeable side effects. He did not use minoxidil due to adverse effects and plans to consider adding dutasteride weekly for further improvement.

      community Hair Growth Journey: 10 months

      in Progress Pictures  250 upvotes 1 year ago
      A 31-year-old who experienced severe hair loss during medical school tried various treatments, including topical and oral finasteride and minoxidil, but stopped due to side effects. They restarted treatment 10 months ago with a regimen including topical finasteride, minoxidil, retinoic acid, hydrocortisone, oral minoxidil, and light therapy, emphasizing the importance of consistency and skincare.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community For the ladies: Spironolactone for FPHL

      in Female  12 upvotes 8 years ago
      A 34 year old female with androgenic alopecia who has tried treatments such as Spironolactone, Desogen, Minoxidil and Finasteride in order to address her hair loss. It also details the experiences of other women taking Spironolactone for Female Pattern Hair Loss (FPHL).

    Similar Research

    5 / 566 results