HIF1A Stabilization in the ORS of Human Hair Follicles Promotes Aerobic Glycolysis and Synthesis of Angiogenic Factors

    April 2019 in “ Journal of Investigative Dermatology ”
    K.F. Shah, Michael G. Davis, A. W. Peplow, Yvonne M. DeAngelis, Michael P. Philpott
    TLDR Stabilizing HIF1A in hair follicles may boost hair growth by enhancing energy production and blood vessel formation.
    The study investigated the role of HIF1A in human hair follicles, focusing on its impact on glycolysis and hair growth. HIF1A, a key regulator of cellular response to hypoxia, was found to promote glycolysis and increase the expression of angiogenic factors like VEGF, which is associated with improved hair growth. The research showed that HIF1A, along with HIF1B and HIF2A, was expressed in the epidermis, sebaceous glands, and hair follicles, with strong nuclear staining in the outer root sheath (ORS). Treatment with iron chelators, which stabilize HIF1A, enhanced this expression and shifted ORS cells from balding scalps to a more glycolytic phenotype, potentially reducing oxidative stress and promoting hair growth. The findings suggested that HIF1A stabilization could be beneficial in addressing hair loss by promoting glycolysis over oxidative phosphorylation.
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