Effects of a Medicinal Herbal Mixture Extract on Hair Growth and Melanin Production

The study investigated the effects of an ethanol extract from a medicinal herbal mixture (SHJ) on hair growth and melanogenesis in C57BL/6 mice and melanoma cells. Mice were treated with SHJ, a vehicle (CON), or 5% minoxidil (MNXD) for 15 days. Results showed that both SHJ and MNXD significantly increased hair density and thickness compared to the vehicle. SHJ also promoted the expression of IGF-1 and VEGF while reducing TGF-β1 expression. Additionally, SHJ increased melanin content and tyrosinase activity in a dose-dependent manner. The findings suggested that SHJ could be a valuable component in cosmeceuticals for enhancing hair growth and pigmentation.