Hairless Descendants of Mexican Hairless Dogs: An Experimental Model for Studying Hypertrophic Scars

November 2011 in “ Journal of Cutaneous Medicine and Surgery ”

Tohru Kimura

hypertrophic scars hairless dogs DOPA-positive melanocytes reepithelialization granulation tissue collagen remodeling elastic fibers

TLDR Hairless dogs can be used to study human hypertrophic scars.

The study explored the use of hairless dogs as a model for human hypertrophic scarring by creating full-thickness wounds on their dorsolumbar skin. The resulting scars were similar to human hypertrophic scars, showing hyperpigmentation, increased activated melanocytes, and collagen and elastic fiber remodeling. These results indicated that hairless dogs could be a suitable model for further research on hypertrophic scarring in humans.

View this study on journals.sagepub.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 53 results

community Verteporfin day 119 update - donor hair regeneration human trial

in Research/Science 146 upvotes 3 years ago

A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

community Does losing your hair make you hit the gym ?

in Satire 2 years ago

How some people start going to the gym when they begin to lose their hair, as well as discussing various treatments (Finasteride, Minoxidil and Dermarolling) for hair loss.

community My 6months progress (good thing I caught it early)

in Progress Pictures 52 upvotes 1 year ago

After 6 months of using 1mg finasteride daily and ketoconazole shampoo twice a week, an individual saw hair loss improvement. They also maintain a good diet and regular gym routine but do not train their calves.

community NW4 -> NW 2.5 (2.5 months progress) RU 8.5-9% ED and topical Dut .1% + RU 5% once a week.

in Progress Pictures 110 upvotes 2 years ago

User shows hair loss progress from NW4 to NW2.5 in 2.5 months using RU 8.5-9% daily and topical Dut .1% + RU 5% weekly. Discussion includes managing tension in African American hair and representation of different hair types.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 147 upvotes 1 year ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community 2022 Official beginner guide for "I'm losing my hair, what can I do?"

in STARTER GUIDE 686 upvotes 3 years ago

Hair loss treatments include Finasteride, Minoxidil, Ketoconazole shampoo, and Microneedling. Additional options are Dutasteride, oral Minoxidil, and hair transplants.

Related Research

1 / 1 results

research Hairless Descendants of Mexican Hairless Dogs: An Experimental Model for Studying Hypertrophic Scars

5 citations , November 2011 in “Journal of Cutaneous Medicine and Surgery”

Hairless dogs can be used to study human hypertrophic scars.