Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib

January 2020 in “ Acta Dermato Venereologica ”

Tanja Fetter, Germán Cuevas-Ríos, Dennis Niebel, Thomas Bieber, Joerg Wenzel

alopecia universalis Janus kinase inhibitor ruxolitinib JAK inhibitors JAK/STAT pathway hair regrowth autoimmune diseases

TLDR Ruxolitinib treatment led to unexpected hair regrowth in a patient with alopecia universalis.

A patient with longstanding alopecia universalis experienced unexpected hair regrowth while being treated for recalcitrant dermatomyositis with the Janus kinase inhibitor ruxolitinib. This case highlighted the potential of JAK inhibitors in promoting hair regrowth in conditions like alopecia universalis, suggesting a possible therapeutic avenue for patients with similar conditions. The findings underscored the importance of further research into the JAK/STAT pathway's role in hair growth and autoimmune diseases.

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Research cited in this study

2 / 2 results

research JAK Inhibitors and Alopecia Areata

56 citations, January 2019 in “Lancet”

JAK inhibitors help regrow hair in alopecia areata patients, improving their quality of life.

research Alopecia Areata: A Review of Disease Pathogenesis

191 citations, May 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata is likely an autoimmune disease with unclear triggers, involving various immune cells and molecules, and currently has no cure.

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