Time to Scalp Hair, Eyebrow, and Eyelash Improvement in Patients with Alopecia Areata Treated with Baricitinib in the Phase 2 Portion of the Phase 2/3 BRAVE-AA1 Study

    August 2021 in “ Journal of The American Academy of Dermatology ”
    Maryanne M. Senna, Amy J. McMichael, Tiffany T. Mayo, Julian Mackay‐Wiggan, Marc Glashofer, Luna Sun, Guanglei Yu, Fabio P. Nunes, Jill Shwed McCollam, Wen‐Chi Wu, Brett King
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    TLDR Baricitinib helped improve hair, eyebrow, and eyelash growth in alopecia areata patients.
    The phase 2 of the BRAVE-AA1 study evaluated the effectiveness of baricitinib, a JAK1/JAK2 inhibitor, in treating alopecia areata (AA) patients. The study involved 82 participants divided into three groups: baricitinib 4-mg (27 participants), baricitinib 2-mg (27 participants), and placebo (28 participants). At week 36, 52% of the 4-mg group, 33% of the 2-mg group, and 4% of the placebo group achieved a Severity of Alopecia Tool (SALT) score ≤20, indicating hair regrowth. In terms of eyebrow and eyelash improvement, 39% and 60% of the 4-mg group, 29% and 40% of the 2-mg group, and 4% and 6% of the placebo group achieved eyebrow and eyelash scores ≤1, respectively. These results suggest that baricitinib may be an effective treatment for AA.
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      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 3 years ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 3 years ago
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