Change In Hair Color In Mice Induced By Injection Of Alpha-MSH

    December 1966 in “ Endocrinology ”
    Irving I. Geschwind
    TLDR Injecting α-MSH made mice's hair turn black.
    The study investigated the effect of α-MSH injections on hair color in mice of the black agouti C3H XAF1 hybrid cross. Mice were injected with 5 X 10^5 U α-MSH twice daily, and it was observed that hair regrowing in shaved and plucked areas during the injection period turned black. The findings were significant in understanding the role of α-MSH in hair darkening and its potential relationship with a circulating agent in animals with a transplantable pituitary tumor.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 124 results
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 4 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

    Related Research

    6 / 6 results