The Hair Loss Encyclopedia

Study of Gonadal Hormone Drugs in Blocking Filovirus Entry of Cells In Vitro

December 2015 in “ PubMed ”

Lili Wang, Qing Chen, Lina Zhou, Ying Guo

gonadal hormone drugs toremifene citrate tamoxifen citrate clomiphene citrate estradiol benzoate raloxifene hydrochloride hexestrol chlormadinone acetate quinestrol

TLDR Some gonadal hormone drugs can block filovirus entry into cells.

The study aimed to identify filovirus entry inhibitors from a library of 1,600 commercial drugs using a ZEBOV-GP/HIV pseudovirus model. It found 12 gonadal hormone drugs with inhibitory effects at a concentration of 10 μmol/L. Notably, toremifene citrate, tamoxifen citrate, and clomiphene citrate showed strong activity with IC50 values below 1 μmol/L. Additionally, these drugs, along with raloxifene hydrochloride and quinestrol, were effective against both Sudan ebola virus and Marburg virus pseudotypes. This research highlighted the potential of certain gonadal hormone drugs as inhibitors of filovirus entry in vitro.

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