Influence of Glucocorticoids on Time-of-Day-Dependent Variation in Intradermal Reactivity to Histamine in Dogs

    May 2016 in “ The Veterinary Journal ”
    Shun Goto, Sunao Shimizu, Miwa Watanabe, Hironari Osada, Kazuaki Sasaki, Minoru Shimoda, Makoto Nagai, Junsuke Shirai, Hiroshi Itoh, Keitaro Ohmori
    TLDR Glucocorticoids affect dogs' skin reactions to histamine, which vary by time of day.
    The study found a significant time-of-day-dependent variation in intradermal reactivity to histamine in dogs, with larger wheal sizes observed at 9:00 h compared to 21:00 h. Administration of exogenous glucocorticoids (prednisolone or hydrocortisone) and inhibition of endogenous glucocorticoids (trilostane) disrupted this variation, suggesting that glucocorticoids from the adrenal glands played a role in regulating this daily variation. The findings indicated that histamine-mediated reactions in dogs varied throughout the day, potentially influenced by circadian rhythms and glucocorticoid levels.
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