Is Growth Hormone a Radioprotective Agent?

    February 2006 in “ Journal of the European Academy of Dermatology and Venereology ”
    SB Tekin, MV Ertekin, Fazlı Erdoğan, Orhan Sezen, İhsan Karslıoğlu, Akçahan Gepdíremen, K. Şerifoğlu, Sare Altaş
    TLDR Growth hormone may protect skin from radiation damage.
    The study investigated the potential of growth hormone (GH) as a radioprotective agent using a radiation-induced skin injury model in rats. Rats were divided into four groups: a control group, a radiation group receiving 30 Gy of gamma irradiation, and two groups receiving the same irradiation plus either 0.01 U/kg/day or 0.02 U/kg/day GH. Results showed that GH significantly reduced the severity of radiodermatitis compared to the radiation-only group, delaying its onset and preventing epidermal atrophy, dermal degeneration, and hair follicle atrophy. These findings suggested that GH could mitigate radiation-induced skin damage, warranting further studies with higher GH doses in cancer patients undergoing radiation therapy.
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