Network-Based Identification of Genetic Effect of SARS-CoV-2 Infections on Idiopathic Pulmonary Fibrosis Patients

    September 2020 in “ Briefings in Bioinformatics ”
    Tasnimul Alam Taz, Kawsar Ahmed, Bikash Kumar Paul, Md Kawsar, Nargis Aktar, Sakib Mahmud, Mohammad Ali Moni
    TLDR SARS-CoV-2 may worsen IPF due to shared genes and pathways, suggesting potential drug targets.
    The study investigated the genetic effects of SARS-CoV-2 infections on patients with Idiopathic Pulmonary Fibrosis (IPF) by analyzing lung epithelium cell datasets. It identified common genes and pathways shared between SARS-CoV-2 and IPF, which could explain the increased severity and mortality in IPF patients with COVID-19. Using bioinformatics tools, the researchers constructed a protein-protein interaction network to detect hub genes and essential modules. They also explored TF-genes and miRNA interactions with differentially expressed genes. Functional analysis revealed shared associations that may contribute to the heightened risk for IPF patients. Additionally, the study suggested potential drug targets for treating IPF patients infected with SARS-CoV-2.
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