Exploring the Frequency and Autoimmune Associations of Lichen Planopilaris

October 2025 in “ Italian Journal of Dermatology and Venereology ”

Yahya Argobi

lichen planopilaris autoimmune associations inflammatory disorder permanent hair loss systemic lupus erythematosus

TLDR Lichen planopilaris is rare, mostly affects older women, and is often linked to autoimmune diseases like lupus.

This study investigated the frequency and autoimmune associations of lichen planopilaris (LPP), a rare inflammatory disorder causing permanent hair loss. Analyzing data from 24,711 charts, 1,549 patients with LPP were identified, indicating a prevalence of 0.02581%. The majority of patients were females over 60 years old, with a significant portion also having autoimmune diseases. Systemic lupus erythematosus (SLE) was the most common autoimmune condition, affecting 55.55% of those with concurrent autoimmune diseases. The findings underscore the importance of further research to enhance management strategies for LPP, particularly in patients with autoimmune conditions.

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