FOXN1 Duplication And Congenital Hypertrichosis

March 2017 in “ Pediatric Dermatology ”

Eimear Gilhooley, S. Gormally, Alan D. Irvine, Sally Ann Lynch, Sinead Collins

FOXN1 congenital hypertrichosis forkhead box gene epithelial cell differentiation keratinocyte regulation hair keratins chromosome 17

TLDR FOXN1 duplication can cause excessive hair growth.

The document reported a case of congenital hypertrichosis associated with FOXN1 duplication. FOXN1, part of the forkhead box gene family on chromosome 17, played a role in epithelial cell differentiation and keratinocyte regulation, particularly hair keratins. Disruption in hair growth occurred due to loss of function in these transcription factors. This was the first reported case linking FOXN1 duplication with congenital hypertrichosis in the literature.

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