Floppy Iris Syndrome
January 2022
in “
Essentials in ophthalmology
”
TLDR Tamsulosin increases the risk of floppy iris syndrome during cataract surgery.
Intraoperative floppy iris syndrome (IFIS) is linked to the use of alpha1-adrenoceptor antagonists, especially tamsulosin, which is used for benign prostatic hyperplasia. Tamsulosin significantly raises the risk of IFIS during cataract surgery compared to other drugs like alfuzosin. Other medications, such as finasteride, silodosin, and some antipsychotics, are also associated with IFIS. Prophylactic measures like atropine or intracameral epinephrine can help reduce the risk. IFIS is marked by a flaccid iris that moves with intraocular fluid currents, causing surgical complications.
