TLDR Tamsulosin increases the risk of floppy iris syndrome during cataract surgery.
Intraoperative floppy iris syndrome (IFIS) is linked to the use of alpha1-adrenoceptor antagonists, especially tamsulosin, which is used for benign prostatic hyperplasia. Tamsulosin significantly raises the risk of IFIS during cataract surgery compared to other drugs like alfuzosin. Other medications, such as finasteride, silodosin, and some antipsychotics, are also associated with IFIS. Prophylactic measures like atropine or intracameral epinephrine can help reduce the risk. IFIS is marked by a flaccid iris that moves with intraocular fluid currents, causing surgical complications.
28 citations,
February 2020 in “Clinical Ophthalmology” Certain medications and patient factors increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery, but with careful planning and technique adjustments, complications can be minimized.
22 citations,
March 2018 in “International Ophthalmology” Taking tamsulosin or finasteride and being older increase the risk of floppy iris during cataract surgery.
29 citations,
May 2011 in “Journal of Cataract and Refractive Surgery” Finasteride may cause cataracts and floppy-iris syndrome.
49 citations,
December 2007 in “Journal of Cataract and Refractive Surgery” Finasteride may cause floppy-iris syndrome during cataract surgery, so check patients' medical history.
11 citations,
February 2004 in “Clinical and Experimental Ophthalmology” Taking Propecia might lead to the development of cataracts.
June 2024 in “Georgetown medical review” Finasteride treats hair loss but may cause low libido, erectile issues, and depression.
June 2017 in “Reactions Weekly” Finasteride (Propecia) may cause depression and suicidal thoughts; stop use and inform a healthcare professional if symptoms develop.
3 citations,
June 2004 in “Annales De Dermatologie Et De Venereologie” Four new cases of gynecomastia (male breast enlargement) linked to finasteride (Propecia) have been found.
Finasteride is popular for treating male hair loss but may increase the risk of serious prostate cancer and has other potential side effects.
2 citations,
January 2003 in “Journal of Clinical Dermatology”
