FLIM Reveals Red Light-Induced Changes In Murine Hair Follicles

    April 2026 in “ Biosensors ”
    Shanjie Xu, A. Wang, Yuxuan Lin, Qichang Lai, Guangchao Xu, Chunhua Peng, Xiao Peng, Wei Yan, Junle Qu
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    Studysummary In this study, red-light irradiation significantly increased hair follicle numbers and ATP levels in a mouse model, highlighting low-level laser therapy's potential to enhance hair regeneration and alter the skin metabolic microenvironment. Our plain-language summary of this paper — not a Tressless recommendation.
    This study investigates the effects of red-light irradiation on hair follicle dynamics using fluorescence lifetime imaging microscopy (FLIM) in a C57BL/6 mouse model. The research demonstrates that 650 nm red-light irradiation significantly increases hair follicle numbers and enhances ATP levels in skin tissue. FLIM analysis reveals prolonged fluorescence lifetime values, indicating significant changes in the skin's metabolic microenvironment. The study highlights FLIM's high sensitivity and accuracy in evaluating hair growth, suggesting its potential as a powerful tool for characterizing the cutaneous microenvironment and assessing phototherapeutic efficacy in future applications.
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