Effects of Finasteride on Microvascular Density and VEGF Expression in Glomeruli of Diabetic Mice

The study investigated the effects of finasteride on microvascular density and VEGF expression in the glomeruli of diabetic mice. Diabetes was induced in mice, which were then divided into groups, including a control group and three treatment groups receiving different doses of finasteride (0.1, 1, and 10 mg/kg). Results showed that diabetic mice had increased glomerular area, volume, microvascular density, and VEGF expression compared to controls. However, treatment with 10 mg/kg of finasteride significantly reduced these parameters compared to the diabetic model group. The study concluded that finasteride inhibited VEGF expression and decreased glomerular microvascular density in diabetic mice.