Finasteride Reduces the Preventive Effect of Uroselective α1A-Blockers Against Cancellous Bone Disorders Induced by Androgen Deficiency in Rats

July 2015 in “ Pharmacological Reports ”

Rafał Miozga, Urszula Cegieła, Joanna Folwarczna, Szymon Piskorz

finasteride androgen deficiency α1A-blockers Propecia

TLDR Finasteride weakens the bone-protective effects of certain blockers in low androgen conditions.

The study investigated the effects of finasteride on the preventive action of uroselective α1A-blockers against bone disorders caused by androgen deficiency in rats. It was found that finasteride reduced the protective effects of these blockers on cancellous bone, suggesting that finasteride might interfere with the bone-preserving benefits of α1A-blockers in the context of androgen deficiency. This research provided insights into the interactions between finasteride and α1A-blockers, highlighting potential implications for the treatment of bone disorders in conditions of low androgen levels.

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Finasteride Reduces the Preventive Effect of Uroselective α1A-Blockers Against Cancellous Bone Disorders Induced by Androgen Deficiency in Rats

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