Fesoterodine: Pharmacological Properties and Clinical Implications
May 2018
in “
European journal of pharmacology
”
Studysummary This study reviewed the pharmacological properties of fesoterodine and found that its ability to effectively treat overactive bladder, especially in the elderly, is likely due to its specific properties, including its receptor affinity, blood-brain barrier penetration, metabolic conversion, and extended-release formulation.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Fesoterodine was recognized for its efficacy and safety in treating overactive bladder (OAB), particularly in the elderly. A systematic review of 205 articles, with 45 selected, highlighted four key pharmacological properties: high and nearly equal affinity for M2 and M3 muscarinic receptors, poor penetration of the blood-brain barrier, rapid conversion to its active metabolite without hepatic first-pass activation, and an extended-release formulation. These properties contributed to its classification as beneficial (B) by LUTS-FORTA 2014, based on six studies involving 2,511 elderly patients, demonstrating low cognitive impact and clear efficacy.
