Feline And Canine Cutaneous Lymphocytosis: Reactive Process Or Indolent Neoplastic Disease?

January 2022 in “ Veterinary Sciences ”

Francesco Albanese, Francesca Abramo, Michele Marino, Maria Massaro, Laura Marconato, Lucia Minoli, Valeria Martini, Luca Aresu

cutaneous lymphocytosis alopecia erythema scales dermal infiltrate lymphocytes CD3+ CD20+ polyclonal clonal rearrangements epitheliotropic lymphoma

TLDR Feline cutaneous lymphocytosis is likely reactive, while canine cutaneous lymphocytosis needs more study to understand its nature.

The study investigated cutaneous lymphocytosis (CL) in 19 cats and 10 dogs to determine if it was a reactive process or an indolent neoplastic disease. In cats, CL was characterized by alopecia and erythema, with polyclonal infiltrates and a median survival of 1,080 days, suggesting a reactive nature. Dogs showed a mix of T- and B-cell infiltrates, clonal rearrangements, and a more variable clinical course, complicating differentiation between CL and cutaneous epitheliotropic lymphoma (CEL). The study concluded that CL in cats was likely reactive, while in dogs, it was more complex, requiring a comprehensive diagnostic approach and further research.

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Research cited in this study

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