Familial Nonmembranous Aplasia Cutis of the Scalp

The document reports on six families where multiple members exhibited familial nonmembranous aplasia cutis of the scalp, a condition characterized by large, irregular defects typically located over the vertex or anterior to the vertex along the sagittal suture. This condition, which can be sporadic, has also been observed to follow an autosomal dominant inheritance pattern. The study highlights that the defects observed in these families were of the nonmembranous variant, which is one of the two main clinical variants of aplasia cutis of the scalp, the other being oval-shaped membranous aplasia cutis. The document also reviews previous reports and clinical pictures of the condition, confirming the nonmembranous type as the more common presentation in familial cases.