Evidence for Two Independent Functional Variants for Androgenetic Alopecia Around the Androgen Receptor Gene

November 2010 in “ Experimental Dermatology ”

J Cobb, Sophie Zaloumis, Katrina J Scurrah, Stephen B. Harrap, Justine A. Ellis

androgen receptor AR male pattern baldness AGA androgenetic alopecia Chr20 region ChrX region

TLDR Two gene areas linked to male pattern baldness found, more research needed.

This study investigated the gene encoding the androgen receptor (AR) and its association with male pattern baldness (AGA). Results showed evidence of two independent loci associated with AGA - one upstream of AR that had been previously described, and a novel downstream region. Further investigation into these non-coding regions is needed to identify functional variants that contribute to AGA, as well as further research into the Chr20 region which appears to have a lesser influence on AGA than the ChrX region.

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