Epimorphin and Epithelial Morphogenesis

January 2007

Zhou Jun

epimorphin syntaxin 2 epithelial morphogenesis MMP3 C/EBPβ MAPK/ERK signaling pathway epidermal growth factor receptor EGFR hair follicle tubulogenesis

TLDR Epimorphin helps shape and develop epithelial cells, like those in hair follicles.

The document discussed the role of epimorphin (EPM), also known as syntaxin 2, in epithelial morphogenesis. EPM, a mesenchymal cell surface-associated molecule, was highly conserved in mammals and involved in morphogenesis by controlling MMP3 and C/EBPβ. Although its signaling pathway was not well understood, it was proposed that EPM might activate the MAPK/ERK signaling pathway by phosphorylating the epidermal growth factor receptor (EGFR). EPM functioned as a key morphoregulator for various epithelial cells, including those in the hair follicle, particularly during tubulogenesis. It could selectively direct branching and luminal morphogenesis, influencing the development and expansion of lumen diameter.

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