Engrailed-1 Promotes Eccrine Sweat Gland Development in Permissive Environments

    April 2016 in “ Journal of Investigative Dermatology ”
    Bradley Morgan, Yana G. Kamberov
    Image of study
    TLDR The Engrailed-1 gene plays a key role in the development of sweat glands in mice.
    The 2016 study "706 Engrailed-1 promotes eccrine sweat gland development in permissive environments" found that the Engrailed-1 (En1) gene, a homeodomain transcription factor, plays a significant role in the development of eccrine sweat glands in mice. The researchers discovered that the relative frequency of eccrine glands and hair follicles is fixed within inbred strains and varies between them. They used QTL analysis to identify a small number of loci that explain much of this variation, with En1 lying within the strongest of these QTLs. Reduction of En1 gene dosage was shown to reduce the frequency of eccrine glands within both test strains in the QTL cross, suggesting that En1 levels in the plantar epidermis directly alter appendage fate. Further tests confirmed that increased En1 expression in the epidermis increases the relative density of eccrine glands and that higher En1 levels can convert the entire population of cutaneous appendages in the region to eccrine sweat glands.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 7 results

      community Verteporfin and Microneedling

      in Treatments 5 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Potential Cure?! Verteporfin- unlimited HT

      in Research/Science  39 upvotes 10 months ago
      The conversation discusses verteporfin as a potential treatment for hair regeneration, which could lead to unlimited hair transplants by healing the donor area. Some users are considering using verteporfin now, while others are hopeful it will be available for future hair transplants.

      community 4+ Years on Dut: Update and AMA

      in Update  113 upvotes 1 year ago
      Hair loss treatments, such as Dutasteride, Minoxidil, and Finasteride. Advice is given to give the medications time to work and to consider a Hair Transplant in order to fill any gaps caused by continuing hair loss.

    Similar Research

    5 / 307 results