TLDR Hormone therapy greatly improves the quality of life for adults seeking gender reaffirmation, but more research is needed in India.
The document discusses the importance of Gender-affirming hormone therapy (GAHT) in managing gender-incongruent (GI) individuals, stating that it significantly enhances their quality of life. However, it notes that research on the outcomes and adverse events of GAHT in adults, particularly in India, is limited and lacks large cohort studies. The document provides medical management protocols for clinicians prescribing GAHT, including guidelines for counseling, baseline evaluation, therapy choice, hormone therapy targets, clinical and biochemical monitoring, and perioperative hormone therapy.
166 citations
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October 2018 in “Endocrine Reviews” Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.
37 citations
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May 2018 in “Transgender health” Oral estradiol works for many transgender women but needs personalized dosing and monitoring.
2170 citations
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September 2017 in “The Journal of Clinical Endocrinology & Metabolism” A multidisciplinary approach is crucial for safe and effective hormone treatment in gender-dysphoric individuals, with specific guidelines for adolescents and adults.
41 citations
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December 2016 in “International Journal of Women's Dermatology” Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.
146 citations
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December 2016 in “Translational Andrology and Urology” Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.
1 citations
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January 2022 in “Transgender health” Hormone therapy in transgender individuals can increase acne and affect hair growth and loss.
October 2023 in “Paediatrics & child health” The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.
1 citations
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November 2023 in “Medicina” Hormone therapy improves mental well-being in transgender individuals but requires ongoing health monitoring.
June 2025 in “CA A Cancer Journal for Clinicians” Transgender men need personalized cancer care and continued testosterone therapy for well-being.
July 2025 in “Indian Journal of Endocrinology and Metabolism” The guideline emphasizes a multidisciplinary approach and informed consent for gender-affirming hormone treatment, with regular follow-ups and individualized care.
