Fabrication of Electrospun Probiotic Functionalized Nanocomposite Scaffolds for Infection Control and Dermal Burn Healing in a Mice Model

This study demonstrated the creation of probiotic-functionalized nanocomposite scaffolds using Enterococcus mundtii QAUEM2808, poly(vinyl alcohol), poly(vinylpyrrolidone), and glycerol through electrospinning. The scaffolds, characterized by various analytical techniques, showed enhanced probiotic survival and degradability in simulated wound fluid, essential for combating pathogens. In a mice model with second-degree burns (n = 30), the bioscaffolds significantly accelerated wound healing, epithelialization, collagen deposition, and hair follicle formation while inhibiting harmful bacteria. The findings suggested that these probiotic bioscaffolds could be a promising approach for infection control and dermal burn healing.