Electron Microscopic Observation of Skin and Hair on a Case of Netherton Syndrome

The study focused on a 21-year-old male with Netherton syndrome, examining skin and hair ultrastructural changes using TEM and SEM. Results showed that the skin's stratum corneum had lamellar bodies, electron-dense granules, and degenerating desmosomes, with corneocyte separation and intracellular lipid droplets. The hair exhibited a bamboo-like structure with broken cuticles. These findings indicated that such ultrastructural changes are characteristic of Netherton syndrome and could aid in its early diagnosis.