El sistema español de autonomías territoriales: apuntes para un diagnóstico

    January 2009 in “ Journal of the American Academy of Dermatology ”
    Juan María Pemán Gavín
    TLDR Generalized trichoepitheliomas with alopecia may indicate myasthenia gravis.
    The document reported on a patient with a syndrome characterized by smooth facial papules and nodules, alopecia of the eyebrows, eyelashes, and most body hair, mild scalp hair alopecia, possibly hypohidrosis, and myasthenia gravis. Fourteen biopsy specimens revealed a lacelike network of basaloid cells with follicular differentiation, similar to classic trichoepithelioma. The tumor cells exhibited a keratin phenotype typical of infrainfundibular outer root sheath cells. The study concluded that the lesions were trichoepitheliomas, suggesting a new syndrome related to generalized hair follicle hamartoma or a variant. The presence of generalized trichoepitheliomas with alopecia should raise suspicion for myasthenia gravis.
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