The Most Efficient Follicular Regenerating Unit and the Smallest Follicular Regenerating Unit: Potential Treatments for Hair Loss

    July 2009 in “ Medical hypotheses ”
    Sen Wang, Yu Liu, JI Ying-chang, Cheng Huang Lin, Cheng Man, Xiaoxuan Zheng
    TLDR Identifying specific hair follicle parts could lead to better hair loss treatments.
    The document discussed hair loss treatments, particularly focusing on hair transplantation. Traditional hair transplantation, which involves moving hair from one part of the scalp to another, does not increase the total number of hairs. The authors hypothesized that more efficient and smaller follicular regenerating units (EFRU and SFRU) could be identified within hair follicles, allowing for a one-to-many transplantation approach. This method, called hair follicle micro-dissection (HFM), aimed to segment hair follicles into parts that could each regenerate new hair, potentially doubling or tripling the number of hairs. If proven practical, this approach could offer a more effective treatment for hair loss.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Hair Cloning, Trials were supposed to begin 2020-2021

      in Technology  48 upvotes 4 years ago
      The conversation discusses hair cloning trials expected to start in 2020-2021 and mentions concerns about potential delays due to the Coronavirus. Treatments like Minoxidil, finasteride, and RU58841 are referenced.

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Related Research

    8 / 8 results