Evaluation of the Efficacy of Transdermal Drug Delivery of Calcipotriol Plus Betamethasone Versus Tacrolimus in the Treatment of Vitiligo

    July 2018 in “ Journal of Cosmetic Dermatology ”
    Zeinab A Ibrahim, Arwa M. Hassan, Hoda Y. Elgendy, Hanan AlSaeid Alshenawy
    Image of study
    TLDR Calcipotriol plus betamethasone with microneedling works better than tacrolimus for treating vitiligo.
    In a study of 25 patients with vitiligo, the effectiveness of transdermal drug delivery of calcipotriol plus betamethasone with microneedling was compared to tacrolimus with microneedling. The study, which lasted 6 months with a 3-month follow-up, showed that the side treated with calcipotriol plus betamethasone (side A) had a significantly higher mean percentage of improvement (72.16%) than the side treated with tacrolimus (side B), which showed a 54.16% improvement. Additionally, 60% of patients on side A experienced excellent improvement compared to 32% on side B. Histopathological examination supported these findings, showing greater expression of the melanocyte marker HMB45 on side A. The study concluded that microneedling with calcipotriol plus betamethasone is more effective than with tacrolimus in treating vitiligo, especially in resistant areas, and is a safe, affordable, and well-tolerated treatment with minimal side effects.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 8 results

      community Anyone used Topical Calcipotriol (cream) or VPA ( Valproic Acid)

      in Chat  8 upvotes 4 years ago
      The conversation discusses using topical Calcipotriol and Valproic Acid for hair loss, focusing on their mechanisms involving the VDR receptor and Wnt/beta-catenin pathway. Specific treatments mentioned are Minoxidil, Finasteride, and RU58841.

      community Using topical vitamin D, does it make sense?

      in Chat  6 upvotes 2 years ago
      Topical Calcipotriol (vitamin D derivative) may help with hair regrowth, especially for alopecia areata. The user wonders if adding classic vitamin D to lotions like Minoxidil could have a similar effect.

      community 8mg on oral finasteride. No results?

      in Progress Pictures  7 upvotes 1 year ago
      A user is experiencing worsening hair loss despite using 8mg of oral finasteride and is considering trying minoxidil or redoing blood work. They are concerned about thinning hair on the sides and back of their head.

      community One year of progress (Fin, 1mg)

      in Is this regrowth?  281 upvotes 3 months ago
      The user started finasteride (1mg) a year ago for hair thinning, experiencing stabilization but not significant regrowth. Suggestions included adding minoxidil, microneedling, and considering a hair transplant for improved results.

    Related Research

    1 / 1 results