Efficacy of Tofacitinib in Pediatric Alopecia Universalis

    May 2017 in “ Journal of the American Academy of Dermatology ”
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    TLDR Tofacitinib helped a teenager with severe hair loss grow hair back, but more research is needed.
    The document described a case study where a 16-year-old male with alopecia universalis (AU), who had not responded to previous treatments, experienced significant hair regrowth after five months of treatment with tofacitinib, a JAK1/3 inhibitor. The patient took 5 mg of tofacitinib orally twice daily and saw hair regrowth on the scalp, eyebrows, arms, and legs, with increased appetite and weight gain as the only side effects. Blood tests remained normal throughout the treatment. This case suggests that JAK inhibitors could be a promising treatment for pediatric AU, but further research is necessary to confirm their efficacy and establish the best treatment protocols.
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      community IGE Hair Loss and Miniaturization

      in Chat  3 upvotes 10 months ago
      A 23-year-old male is experiencing diffuse hair loss and miniaturization, possibly due to high IGE levels after using tofacitinib. He seeks advice and has not yet consulted a dermatologist.

      community Topical solution recommendation

      in Treatment  2 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community Topical solution recommendation

      in Product  1 upvotes 6 months ago
      The user is using finasteride 1mg every other day and seeks a topical solution to complement it, excluding minoxidil. They are considering various combinations of ingredients like finasteride, dutasteride, and tofacitinib, with options for nourishing oils and other additives.

      community can someone help me identify these pls

      in Treatment 3 months ago
      The user is experiencing diffuse thinning and inflammation despite using 2.5mg dutasteride daily, ciclopirox, and ketoconazole shampoos. They are considering treatments like hydroxychloroquine and JAK inhibitors due to suspected scarring alopecia and have faced challenges in obtaining a scalp biopsy.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       6 upvotes 9 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

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