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GlossaryJAK inhibitor

blocks enzymes involved in immune response and inflammation

A JAK inhibitor, also known as a Janus kinase inhibitor or JAKi, is a type of medication that blocks the activity of Janus kinase enzymes. These enzymes play a crucial role in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage autoimmune diseases and conditions like alopecia areata, where the immune system mistakenly attacks hair follicles.

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research Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata

13 citations, September 2022 in “Frontiers in immunology”

Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.

research The Effect of JAK Inhibitor on Survival, Anagen Re-Entry, and Hair Follicle Immune Privilege Restoration in Human Dermal Papilla Cells

16 citations, July 2020 in “International Journal of Molecular Sciences”

Ruxolitinib may help treat hair loss by reducing inflammation, promoting hair growth signals, and protecting hair follicle immunity.

$Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib$

research Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib

6 citations, April 2021 in “Frontiers in Immunology”

A patient with lupus and long-term hair loss saw significant hair regrowth after using the drug tofacitinib.

research Efficacy of Tofacitinib in Pediatric Alopecia Universalis

1 citations, May 2017 in “Journal of the American Academy of Dermatology”

Tofacitinib helped a teenager with severe hair loss grow hair back, but more research is needed.

research IL-15 Prolongs Hair Growth and Acts as a Guardian of Human Hair Follicle Immune Privilege

July 2022 in “Journal of Investigative Dermatology”

IL-15 helps maintain hair growth and protects the immune status of hair follicles.

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