Efficacy and Safety of Switching from Baricitinib to Ritlecitinib in Severe Alopecia Areata

December 2024 in “ Clinical and Experimental Dermatology ”

Ying Chen, Qiuyun Xu, Xiaoqing Lv, Ze‐Hao Zhuang, Siyi Bao, Jing Mao, Ting Gong, Chao Ji

baricitinib ritlecitinib JAK1/2 inhibitor JAK3/TEC inhibitor alopecia areata hair regrowth

TLDR Switching to ritlecitinib improves hair regrowth and well-being in severe alopecia areata patients.

The study examines the effects of switching from baricitinib, a JAK1/2 inhibitor, to ritlecitinib, a JAK3/TEC inhibitor, in patients with severe alopecia areata who had inadequate or no response to baricitinib. The findings demonstrate that ritlecitinib significantly improves hair regrowth, quality of life, and psychological well-being in these patients. The study suggests that a lack of response to one JAK inhibitor does not necessarily predict failure with another, indicating potential for ritlecitinib as an effective treatment option for severe alopecia areata.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

April 2019 in “International journal of research in dermatology”

A child with rough nails also had hair loss and allergies.